The complex physicochemical studies on the composition of hydrothermal waters of the Uchkyzyl, Khaudag, Kakayty, and Lialmicor deposits in the Surkhandarya basin were carried out in the article. The medium, content, mineralization of some underground saline hydrothermal and associated oil waters, as well as the content of iodine and bromine in their composition in the Republic of Uzbekistan were studied.